By: Saijun Huang, Chun-Juan Shi, Bao-Ying Zhong
Keywords: Antibacterial drugs; Blood concentration; Drug efficacy; Nursing cooperation; Postoperative infection in orthopedics
DOI : 10.36721/PJPS.2025.38.6.REG.14894.1
Abstract: This study aimed to explore the effect of a targeted collaborative nursing scheme of antimicrobial agents combined with physical cooling on drug efficacy and patient comfort during the postoperative infection period of orthopedic patients. A total of 150 patients with postoperative infection in the Department of Orthopedics of Zhejiang Provincial Tongde Hospital from January 2023 to January 2024 were selected and randomly divided into a control group (75 cases) and an observation group (75 cases). The control group received conventional antimicrobial treatment and basic nursing care, while the observation group received a collaborative nursing program of antimicrobial treatment combined with physical cooling on the basis of the control group. Compared with the control group, the observation group showed significantly shorter onset time, infection control time and temperature recovery time of antimicrobial drugs (P<0.05); significantly higher General Comfort Questionnaire (GCQ) scores (P<0.05); significantly lower incidence of adverse reactions (P<0.05); and significantly higher blood concentration compliance rate of different antimicrobial drugs (P<0.05). This collaborative nursing can significantly improve the efficacy of antimicrobial drugs, accelerate infection control, enhance patient comfort and reduce the risk of adverse reactions, with important clinical promotion value from a pharmaceutical perspective.
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